Van de Ven Brace Halts The Toffees' Run at Brand New Stadium
The Dutch defender became the first defender to score twice in a Premier League game for Spurs since the Belgian defender in spring 2013.
At a glance
The Spurs defender heads home two times in opening period
The home side's Jake O'Brien has goal disallowed after video check
Senegalese midfielder scores final goal in 89th minute
The defeat is the Merseyside club's initial at Hill Dickinson Stadium
The Tottenham defender scored on two occasions as Tottenham extended their unbeaten run in away games in the Premier League and delivered the Toffees their initial loss at their new home.
Everton were undefeated in their five previous fixtures at their recently opened stadium at Bramley-Moore Dock, having departed their historic home behind after more than a century at the conclusion of the previous campaign.
But Spurs captain the Dutchman struck on two occasions from corners in the first half to put their impressive record at risk, and they were failed to mount a comeback before the midfielder - set up by former Toffees attacker the Brazilian - headed home a final goal to seal the victory.
The Everton defender thought he had levelled the tally a short while after the defender's first goal, glancing a powerful header past the Spurs keeper from an Everton corner.
Beto, meanwhile, missed a handful of opportunities, while Vicario made a succession of excellent saves to guarantee the London club went five away games without defeat in the Premier League.
But the video assistant referee stepped in, advising the match official to review the goal on the pitchside monitor and the official decided that the winger and the attacker were in offside positions and had impeded with the Tottenham goalkeeper.
The win moves Thomas Frank's side into third place in the division, five points off local foes and table-toppers the Gunners.
Everton remain in 14th position and are half a dozen points clear of the drop zone.
Tottenham analysis: Van de Ven fulfils duties at both ends of pitch
Following a uninspiring midweek performance in the European competition against the French side, where they managed a mere attempts on target, Frank opted for the French striker up front instead of former Toffees player Richarlison.
The summer signing was unable to influence the game before being replaced for Richarlison after 60 minutes on the field, but it emerged he proved unnecessary in the end.
Centre-back Van de Ven transformed into an attacking force to be reckoned with.
Spurs' opening strike came from a well-worked set-piece play, with the midfielder heading the ball back across the face of goal for an unmarked Van de Ven to head home.
And Ven de Ven - stepping up as skipper in Cristian Romero's absence - added his next goal in added time as he outjumped the England keeper to nod in.
The Dutchman was just as impressive in defence, partnering well with Kevin Danso as the pair dealt excellently with the numerous deliveries sent their way by Everton.
Toffees breakdown: Toffees missing striker's instinct
The club's recent stadium had been a fortress, but it seems the novelty may have faded slightly and supporters headed to the gates after Sarr's final goal for Spurs.
The end in Everton's unbeaten home run won't be a massive concern for the manager, but their striker situation will be.
The forward and the other striker - the Toffees' pair of established strikers - had scored just a single goal between them before Sunday's match.
And they were failed to add to that poor record on a wet and gloomy night on Merseyside.
The striker's performance was summed up when he chose to overhead kick a golden opportunity from near the goal, despite having room and time to reposition for a simpler shot that would have challenged the keeper.
The substitute, as well, was unable to make an impact after replacing the starter in the 65th minute.
It wasn't for a lack of chance. The majority of the home side's attacks came through the winger and the forward, who tirelessly delivered dangerous crosses into the Tottenham penalty area.
What next for these two sides?
Everton: Moyes' men travel to Sunderland in the Premier League on early November at 20:00 GMT.
Spurs: The London club travel to St James' Park on Wednesday, 29 October for their next round League Cup match against the Magpies.